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Background and purpose : Evaluation of the efficacy of combined hyperthermia and radiotherapy (TRT) in high-risk breast cancer patients with microscopic involved margins (R1) after mastectomy or with resected locoregional, early recurrence with close margins or R1-resection. Main endpoint was...
The term ‘extreme’ whole-body hyperthermia (WBH) describes the procedure of raising a patients’ body-core temperature to 41.5–42.0°C for 60 min. WBH represents the only hyperthermia technique that enables systemic heat treatment in patients with disseminated malignancies and is,...
Treatment of tumours greater than 2 cm by radiofrequency (RF) or microwave ablation typically use multiple sequential applications, since most currently available ablation devices are limited to use of a single applicator at a time. A major focus of current ablation research is on methodologies...
Thermally-induced large blood flow increases and oscillations have been experimentally observed in both muscle and prostate tissues. However, the bio-physical/-chemical mechanisms underlying these phenomena remain undiscovered. To study the basic nature of these coupled thermal-mass transport...
The acute effects of hyperthermia on intracellular Na + (Na ), bioenergetic status and intracellular pH (pH i ) were investigated in superfused Radiation Induced Fibrosarcoma–1 (RIF-1) tumour cells using shift-reagent-aided 23 Na and 31 P nuclear magnetic resonance (NMR) spectroscopy....
The objective of this work is to gain insight in the distortions on the local SAR distribution by various major anatomical structures in the neck. High resolution 3D FDTD calculations based on a variable grid are made for a semi-3D generic phantom based on average dimensions obtained from...
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