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The influence of local hyperthermia (HT) on Mitoxantrone (MITOX) effectiveness was studied in an experimental rat tumour. R-1 rhabdomyosarcomas were treated with MITOX (5 mg/kg ip), HT (43°C for 1 h) or combinations applied at various time intervals up to 24 h. Tumour growth delay and tumour...
The Effective Field Sizes (EPS) and the Effective Heating Depths (EDH) of Contact Flexible Microstrip Applicators (CFMA), tuned at a frequency of 434 MHz, were determined on two fat/muscle phantoms. One phantom was box-shaped with a flat top layer of 1 cm thick artificial fat and the other one a...
A stochastic model describing the probability of cell survival as a function of thermal exposure was developed and fit to data arising from studies of CHO cell survival under hyperthermic conditions. This model characterizes the separate risks of temperature-induced cell death and induction of...
Two pairs of human tumour-cell lines consisting of a cisplatin sensitive and resistant line from glioma and ovarian carcinoma were tested to determine the effect of hyperthermia on cisplatin sensitization. Both cisplatin resistant lines were more sensitive to 42°C heating than their cisplatin...
Twenty-three patients with recurrent breast cancer participating in a Phase III trial evaluating radiotherapy (XRT) with or without hyperthermia (HT) were included in a parallel study of heat shock protein (hsp) expression. The patients had core biopsies and/or fine needle aspirates (FNA)...
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