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Fifty-four patients with 65 superficial malignant lesions were treated by local hyperthermia combined with radiation therapy at the National Cancer Center Hospital, Tokyo. Hyperthermia was delivered with an Aloka Model HMS-020 (2450 MHz) or with a horn-type applicator of BSD-1000 (80–90 MHz)....
One hundred and fifteen cutaneous or lymph node metastases from malignant melanoma were treated with three fractions of irradiation alone in 8 days (62 tumours) or followed by heat either immediately (simultaneous treatment, 26 tumours) or after an interval of 3–4 h (sequential therapy, 27...
The effect of one to five multiple heatings on blood flow in the RIF-1 tumour, skin and muscle of C3H mice was studied. When heated for 1 h at 43.5°C the tumour blood flow increased 1.8 times, and rapidly decreased after the heating to less than half the control value. The 2nd-5th heatings at...
Whole body hyperthermia was induced in older, tumour-bearing dogs using a radiant heat device. Dogs were anaesthetized (thiopental), paralysed (atracurium), and mechanically ventilated (100 per cent O 2 ) during the heating procedure. Heart rate, systolic/diastolic, and mean arterial blood...
Antiproliferative activity of recombinant murine interferon-β (Rec-MuIFN-β) combined with hyperthermia against Rous sarcoma virus-induced mouse malignant glioma (RSV glioma) was investigated both in vitro and in vivo. In vitro , the antiproliferative activity of Rec-MuIFN-β was enhanced by...
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