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Cytotoxic elimination of dendritic cells (DC) in lymphoid tissue represents an important pathway of immune regulation. However, the mechanism of DC removal is still controversial since mature DC are insensitive to death receptor‐mediated killing and other surface or soluble molecules mediating...
Lymphotoxin (LT) and tumor necrosis factor (TNF) are important in immune system development and function. LT consists of soluble LT‐α 3 , which binds to TNF‐R1 and TNF‐R2, and membrane LT‐α 1 β 2 , which binds to LT‐β‐R. We investigated the role of LT and TNF in disease induced by...
CD100/Sema4D belongs to the semaphorin family, factors known to act as repulsive cues for axons during neuronal development. Mouse CD100 plays a crucial role in both humoral and cellular immunity through ligation of the lymphocyte receptor, CD72. It remains controversial, however, whether human...
The vitamin A metabolite, retinoic acid (RA), affects T h 1 and T h 2 development. The effect is partly exerted through the modulation of antigen‐presenting cell functions, but it remains unclear whether RA directly exerts its effect on T cells to influence T h 1/T h 2 development. To clarify...
Platelet factor 4 (PF4) is a CXC chemokine secreted by activated platelets. PF4 has been shown to promote monocyte survival and induce the differentiation of monocytes into macrophages. However, the effect of PF4 on differentiation of monocytes into dendritic cells (DC) has yet to be determined....
Severe combined immunodeficiency (SCID) mice were used to analyze the role of NK cells in resistance to Mycobacterium avium . The neutralization of IFN‐γ in these animals led to an exacerbation of the infection associated with a reduction in macrophage activation, suggesting a role for NK...
B cell autoreactivity is a component of chronic graft versus host (GVH) disease in humans and mice. Chronic GVH driven by I‐A disparity results in loss of B cell tolerance in Ig/sHEL tolerant mice. In these mice, B cell anergy is characterized by down‐modulation of sIgM mediated by...
Histamine is an important mediator released from activated mast cells provoked by allergen and has a substantial role in the pathophysiology of asthma. However, several lines of evidence indicate that histamine could also have important functions in the regulation of basic cell biological...
Previously we have described the role of two 14mer peptides in autoimmune uveitis, PDSAg from the retinal autoantigen S‐antigen (S‐Ag) and B27PD from the sequence of disease‐associatedHLA‐B molecules, which show antigenic mimicry. The retinal peptide gave rise to severe uveitis in the...
The IgG2a Ig subclass plays a critical role in the pathogenesis of humoral autoimmunity and protection against pathogens. The T‐box transcription factor T‐bet has been implicated as a critical mediator of class‐switch recombination (CSR) to IgG2a, but its relative importance to this process...
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