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The MHC class II transactivator (CIITA) plays a central role in adaptive immune responses by controlling the expression of MHC class II genes. CIITA binds DNA‐binding proteins and co‐activator proteins to form an enhanceosome complex necessary for MHC class II gene expression. Here we...
Self versus non‐self discrimination is a key feature of immunorecognition. Through TCR‐activated apoptotic mechanisms, autoreactive thymocytes are purged at the CD4 + CD8 + double‐positive (DP) precursor stage prior to maturation to CD4 + or CD8 + single‐positive (SP) thymocytes. To...
Chemokines displayed on the luminal surface of blood vessels play pivotal roles in inflammatory and homeostatic leukocyte trafficking in vivo . However, the mechanisms underlying the functional regulation of chemokines on the endothelial cell surface remain ill‐defined. A promiscuous chemokine...
IgE plus antigen‐stimulated mast cells degranulate, synthesize leukotrienes and secrete cytokines. According to the coalescence model this process is initiated in specific membrane compartments termed rafts. There, enhanced levels of glycosphingolipids and cholesterol stabilize the interaction...
A humanized murine model was developed to study T cell tolerance to the hepatitis B surface antigen (HBsAg) that is present in sera of hepatitis B virus chronic carriers. The HBsAg/HLA‐A2 double‐transgenic mice express a chimeric HLA‐A2 MHC class I molecule and a high amount of the HBsAg in...
Previous studies have suggested that defective immune responses in early life may be related to the immaturity of neonatal antigen‐presenting cells. To test this hypothesis, we assessed the capacity of neonatal dendritic cells (DC) to prime and polarize in vitro human naive antigen‐specific T...
Ag85B (also known as α antigen or MPT59) is immunogenic, and induces expansion and differentiation of TCRVβ11 + CD4 + T cells to IFN‐γ‐producing cells in C57BL/6 (I‐A b ) mice. We reported that Peptide‐25 (amino acids 240–254) of Ag85B is a major T cell epitope, and its amino acid...
CD22, a B cell‐specific member of the Siglec family, is an important inhibitor of B cell signaling. The first Ig‐like domain of CD22 specifically binds to α2,6‐linked sialic acids. Through these interactions CD22 can mediate adhesion to other cells in trans , but can also bind endogenous...
We report in this work that a cellular and humoral autoreactive response can be induced against liver‐specific self‐determinants by repeated immunization with a chimeric tissue‐specific self‐antigen carrying a heterologous T h epitope. Epitope spreading rendering the autoimmune reaction...
A number of studies in animal models and humans have shown that both humoral andcell‐mediated immune responses play an important role in the control of viral infection and tumor development. In most cases, vaccination with non‐vectorized peptides or proteins induces low antibody responses and...
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