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The matrix metalloproteinases (MMP) are enzymes crucial for the physiological patrol as well as pathological chemotaxis of immune cells to target tissues. The present study examined differential effects of pro‐inflammatory (IL‐18, IL‐12 and tumor necrosis factor (TNF)‐α) versus...
Dendritic cells (DC) express a number of P2X receptors including the P2X 7 /P2Z receptor whose activation by extracellular adenosine 5′‐triphosphate (ATP) induces the influx of calcium, DC maturation, cytokine release and apoptosis. In B lymphocytes ATP induces the rapid shedding of CD23 and...
FTL‐1, ‐3 and ‐10 are three murine day 14 fetal thymocyte cell lines produced in order to model developmental stages within early (CD3 – CD4 – CD8 – ) thymocyte differentiation. In this study, we used the serial analysis of gene expression (SAGE) method to perform a systematic...
Thymectomy on day 3 after birth (d3tx) depletes CD4 + CD25 + regulatory T cells leading to multiple independent organ‐specific autoimmune diseases. However, systemic autoimmune disease such as systemic lupus erythematosus has not been reported in d3tx mice. Herein, we investigate the effect of...
In order to identify new molecules involved in regulation of T cell proliferation, we generated various mAb by immunization of mice with the T cell line Molt4. We found one mAb (termed P‐3E10) that down‐regulated the in vitro T cell proliferation induced by CD3‐specific OKT3 mAb. The...
To attain one of the final goals for cancer immunotherapy, cytotoxic T lymphocyte (CTL) clones were selected on the basis of exogenous IL‐2 independence after limiting dilution culture from mixed lymphocyte tumor cell culture cells of FBL‐3 tumor‐immune spleens. About 10% of the clones...
MHC class II‐restricted autoreactive T cells play a major role in the development of autoimmune diabetes mellitus in both human and mouse. Two of our groups previously established panels of islet‐reactive CD4 + T cell clones from prediabetic non‐obese diabetic (NOD) mice. These clones...
In vaccine development, a major objective is to induce strong, specific T cell responses. This might be obtained by targeting antigen to cell surface molecules that efficiently channel the antigen into endocytic compartments for loading of MHC molecules. Antibodies have been used to deliver...
During the germinal center (GC) reaction a characteristic morphology is developed. In the framework of a recently developed space‐time model for the GC, a mechanism for the formation of dark and light zones has been proposed. There, the mechanism is based on a diffusing differentiation signal...
Lesional skin of patients with atopic dermatitis (AD) is histologically characterized by hypertrophy of the skin, and the infiltration of a large number of eosinophils and T cells into the dermis. Recent studies have indicated that T h 2 cells play a crucial role in the pathogenesis of AD skin....
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