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Analysis of formal amino acid sequence identity between different TCRB chain (TCRB) hypervariable regions (CDR3) is commonly used to localize relevant sites of TCR antigen interaction or to yield indirect information on unknown corresponding antigens. However, this analysis sometimes fails to...
In vivo administration of HgCI 2 causes autoimmune manifestations in susceptible rats and mice. We have, previously shown that mercury is a unique molecule that can primarily activate murine T lymphocytoes to transformation and proliferation in vitro . To test whether a specific TCR repertoire...
Monoclonal non-specific suppressor factor (MNSF), a lymphokine produced by a murine hybridoma, was originally found to inhibit the generation of lipopolysaccharide (LPS)-induced 1g-secreting cells. Most recently, we demonstrated the recombinant form of the ubiquitin-like segment (rUbi-L) of...
Human CD38 is a transmembrane glycoprotein involved in lymphocyte activation and adhesion to endothellum. The ectocellular domain of the molecule posessrs properties of a bifunctional enzyme catazying both the synthesis from NAD + and the hydrolysis of the calcium-reteasing metabolote cyclic...
Several recent reports support the hypothesis that apoptosis occurring in leukocytes of human immunodeficiency virus type 1 (HIV–1)-infected individuals is important in progression to AIDS. Specifically, apoptosis of uninfected bystander cells appears critical in the pathogenesis of disease....
CD4 + CD8 + double-positive thymocytes differentiate into CD4 + and CD8 + single-positive T cells during thymic positive selection. This process requires the interaction between the TCR and self MHC molecules. In this context we have anaiyzed the expression of CD45, an abundant transmembrane...
It has been known for some time that single mutant nude or CD40T mice have apparently normal numbers of cells in the precursor compartments of bone marrow and the mature B cell compartments of the periphery. X-linked immunodeficiency (XID) mice are deficient only in some of the slgM+slgD+ B...
Ligation of the CD2 cell surface glycoprotein expressed on T lymphocytes and NK cells induces protein tyrosine phosphorylation and activation of the Src kinases, LCK and FYN. We show here that in Jurkat T leukemia cells and in peripheral blood T cells, CD2 stimulation also leads to tyrosine...
The conformation of peptides when bound to different HLA class II molecules is of interest in the study of specificity and function of responding T cells. Here, we report the investigation of the HLA-DR binding profiles of an immunodominant and HLA-promiscuous mycobacterial peptide, p38G. Its...
Previous studies from our laboratory have demonstrated a predominant response to myelin oligodendrocyte glycoprotein (MOG) in patient6s with multiple scleros(MS) and showed that this molecule is able to Induce in Lewis rats a chronic relapsingMS-like disease with extensive demyelination. To...
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