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Mice were exposed to an aerosol of fluorescent polystyrene microspheres with nominal diameter 0.89 mum. At 1, 5, 20, and 156 days after exposure, groups of mice were injected with 5-bromo-2'-deoxyuridine (BrdU) and killed 1 h later. The lungs were excised and lavaged with physiological saline to...
There have been reports on the induction of production of tumor necrosis factor (TNF) and interleukin (IL) 1 in macrophages by fibrogenic dusts, such as those from asbestos, man-made fibers and mineral particles, suggesting that release of TNF- and IL-1 from alveolar macrophages may be relevant...
Generation of stable, low concentrations of dry particulates in nose-only chambers can be difficult, and if the supply of particulate is limited, the problems can be greatly increased. One problem is that many dry-particulate aerosol generators have higher aerosol output or airflow than can be...
Recent epidemiological evidence of associations between increased mortality and ambient particle concentrations suggests that ultrafine particles (smaller than 1 mum diameter) and their constituents are potentially significant contributors because of their enhanced toxicity and their potential...
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