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The pulmonary effects and fibrogenic potential of intratracheally instilled silicon compounds were evaluated at 3, 7, 74, and 28 days post instillation. Evaluations consisted of examination of lavaged cell populations, as well as biochemical and histologic techniques. Alpha-quartz (SiO 2 ), a...
Sprague-Dawley rats were exposed nose-only for 1 h/day on weekdays for 13 weeks to the smoke from test and reference cigarettes. The test cigarette was a new prototype: the tobacco is heated rather than burned. The University of Kentucky 1R4F cigarette was used as a reference. The exposures used...
The effect of depleting lung ascorbic acid (AH 2 ) and nonprotein sulfhydryls (NPSH) on the acute inhalation toxicity of nitrogen dioxide (NO 2 ), ozone (O 3 ), and phosgene (COCl 2 ) was investigated in guinea pigs. The increase in bronchoalveolar lavage (BAL) fluid protein (an indicator of...
To evaluate the potential health hazard of two anthraquinone dye mixtures to be used in smoke grenades, five short-term tests were conducted using Fischer 344 rat pulmonary cells in culture. The five tests were designed to measure dye effects on (1) rat tracheal epithelial cell colony forming...
In this study the effects of phosgene inhalation on host resistance models representative of bacterial, viral, and neoplastic lung diseases were assessed. A single Ch exposure to concentrations of phosgene of 0.025 ppm and above significantly enhanced mortality due to laboratory-induced aerosol...
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