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In Japan, the maternal mortality rate from preeclampsia is still high. In this study, we analyzed the clinical background of 70(1.5%) cases of severe preeclampsia in 4, 633 deliveries in our clinic. The main family history was hypertension(34.2%). The medical complication of this pregnancy were...
The effect of a simultaneous infusion of prostaglandin E 1 (PGE 1 ) on the pressor response to angiotensin II (AII) has been studied in 8 pregnant and six non-pregnant subjects to date. PGE 1 15 ng kg −1 min −1 had no effect on basal blood pressures in the pregnant patients, but increased...
Studies in vitro suggest that pregnancy induced hypertension, or toxemia, is associated with decreased placental pros-taglandins E (PGE) levels. To validate this observation in vivo PGE were measured weekly in 24h urine collections, in a prospective cross-sectional study in 9 women from 7 to 40...
In vivo platelet activation by circulating immune complexes has been suggested as one of the underlying mechanisms in pre-eclampsia. Using a modification of the polyethylene glycol protein-A immune complex assay, inmune complexes were found in excess of the equivalent of 20 µg/ml heat aggregated...
Central hemodynamics during late pregnancy were studied in normotensive rats and in rats with short-standing and “established” renal hypertension.
The study was carried on 25 primigravidae with severe pre-eclamptic toxaemia (PET) and 19 normal pregnancies as a control group. 15 cases of PET were treated by 600 mg. progesterone daily for variable duration between one and six weeks. Daily blood samples were assayed for progesterone,...
Eclampsia is still very prevalent in Northern Nigeria, constituting the third commonest cause of maternal deaths with a mortality rate of 9-10% annually. In order to identify some factors that may be associated with maternal deaths in eclamnsia in this region, nine deaths that occurcd during a...
We have measured simultaneously plasma renin activity (PRA), aldosterone and catecholamines in the plasma of 3 groups of pregnant women after the 20th week:group 1 of 16 normotensive controls, group II of 17 women with rest responding hypertension (RRH), group III of 18 women with permanent...
The decreased vascular response to angiotensin II that characterizes normal pregnancy is lost in pregnancy induced hypertension and associated with an increase in response to norepinephrine. These alterations in vascular responsiveness have not been thoroughly investigated and are poorly...
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