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In an international collaborative study, four preparations of recombinant, human sequence, platelet-derived growth factor-BB (PDGF-BB), two glycosylated and two nonglycosylated, were evaluated, using in vitro bioassays and immnunoassays, by seven laboratories in three countries, for their...
Fibroblast growth factors (FGFs) probably play an important role in development and maintenance of the vasculature of the corpus luteum (CL). The objective of the present study was to evaluate the distribution and levels of fibroblast growth factor receptors (FGFRs) in the ovine CL from the...
Polysome analysis indicates that the major 2.4 kb transforming growth factor-β1 (TGF-β1) transcript is poorly translated, both in cultured cells, and in vivo in mouse liver. In contrast, the TGF-β2 transcripts are efficiently translated. The contribution of the 5′-and 3′-untranslated...
We have previously described a non-classical, promoter-specific enhancer for the human Platelet-Derived Growth Factor B (PDGF-B) gene. In JEG-3 choriocarcinoma cells the activity of the enhancer depends upon co-operation with a sequence (the Enhancer-Dependent cis Co-activator “EDC element)...
An immunohistochemical and semiquantitative comparative study of transforming growth factor β (TGF-β) and its receptor types I (TGF-βRI) and II (TGF-βRII) was carried out in normal prostates and in the prostates from men with benign prostatic hyperplasia (BPH), and men with prostatic...
To elucidate the properties of the Src-family member Bsk/Iyk, NIH3T3 cells were transfected with wild-type Bsk/Iyk or Bsk/Iyk carrying Y497F, Y504F or Y497/504F mutations. These positions are putatively homologous to tyr-527 in Src. The Bsk/Iyk Y497/504F cells displayed a decreased cell growth...
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