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Aim: The aim of this study was to evaluate the role of polymorphisms of tumor necrosis factor-related apoptosis-inducing ligand ( TRAIL ) and death receptor ( DR4 ) genes in bladder cancer susceptibility in a Turkish population. Materials and Methods: The study group included 91 bladder cancer...
Aim: To explore whether the aberrant DNA methylation status in plasma could be used as a biomarker for hepatocellular carcinoma (HCC) screening among high-risk individuals. Methods: The promoter methylation status of ELF , RASSF1A , p16 , and GSTP1 was investigated by methylation-specific...
Aims: Chronic renal failure causes patients to become dialysis dependent, which is exhausting for them both financially and psychologically. However, the definitive treatment of chronic renal failure is transplantation. One of the crucial factors affecting success in transplantation is the...
Epidermal growth factor receptor (EGFR) mutations can affect the therapeutic efficacy of drugs used to treat nonsmall-cell lung cancer (NSCLC). We aimed to develop methods to detect five common EGFR somatic mutations in tumor tissues from NSCLC patients by using a nanoscale mutation-sensitive...
Aims: The Wnt planar cell polarity (PCP) pathway is one of the Wnt pathways which plays a critical role in cell proliferation and fate. The VANGL1 protein is one of Wnt-PCP pathway components. It is known that Wnt-PCP pathway has major roles in cell motility but its role in hepatocellular...
Background: Previous studies investigated the associations of interleukin-10 ( IL-10 ) polymorphisms with different types of cancer, indicating an influence on cancer risk. IL-10 -3575T>A (rs1800890) has been studied concerning a potential implication in terms of some cancer site risks, but the...
Aim: The aim of this study was to investigate the predictive value of the rs1805124 polymorphism of the SCN5A gene with regard to idiopathic cardiac conduction disorders. Results: The AG genotype frequency was significantly higher in patients with an atrioventricular block (61,2%±6,0%) compared...
The renin–angiotensin system contributes to cell growth, proliferation, and differentiation in the bone marrow. We investigated the role of the ACE I/D gene polymorphism in 108 polycythemia vera (PV) and essential thrombocytosis (ET) patients who were positive for the JAK2V617F mutation, with a...
Background/Aim: Recent evidence suggests that survivin, a member of the inhibitors of apoptosis family that prevents cell death and regulates cell division is implicated in the pathogenesis of inflammatory bowel disease (IBD). The aim of the study was to identify a possible association between...
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