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Haplotype inference for tightly linked markers from general pedigrees remains a challenging problem. Only a few methods are available to efficiently and accurately estimate haplotype frequencies and reconstruct haplotypes for a large number of tightly linked markers from general pedigrees in the...
An omnibus permutation test of the overall null hypothesis can be used to assess the association of an entire ensemble of genetic markers with disease in case‐control studies. In this approach, p‐values for univariate marker‐specific Armitage trend tests are combined to form a scalar...
The multipoint lod score and mod score methods have been advocated for their superior power in detecting linkage. However, little has been done to determine the distribution of multipoint lod scores or to examine the properties of mod scores. In this paper we study the distribution of multipoint...
The ratio of male and female genetic map distances varies dramatically across the human genome. Despite these sex differences in genetic map distances, most multipoint linkage analyses use sex‐averaged genetic maps. We investigated the impact of using a sex‐averaged genetic map instead of...
Linkage analysis provides an important tool for mapping genes for complex disease. However its usefulness has been limited by inadequate marker density, inadequate sample sizes and the possibility that different genes account for different subtypes of the disease (phenotypic heterogeneity). The...
The ordered subset analysis (OSA) method allows for the incorporation of covariates into the linkage analysis of a dichotomous disease phenotype in order to reduce genetic heterogeneity. Complex human diseases may involve gene‐environment (G × E) interactions, which represent a special form of...
This paper discusses the theory and implementation of a model for mapping X‐linked quantitative trait loci (QTL). As a result of X inactivation, a female's body is subdivided into a number of patches. In each patch one of her two X chromosomes is randomly switched off. This smooths the allelic...
Pulse pressure (PP) is an independent risk factor for cardiovascular disease. PP rises with age, more so in women. We examined sex differences in the correlations and variance components of PP in adult subjects from 767 nuclear families, enriched with those containing twins, from the Victorian...
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