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This study compared the performance of the maximum lod (MLOD), maximum heterogeneity lod (MHLOD), maximum non‐parametric linkage score (MNPL), maximum Kong and Cox linear extension (MKClin) of NPL, and maximum Kong and Cox exponential extension (MKCexp) of NPL as calculated in Genehunter 1.2...
Comorbidity, the association of two disorders, occurs commonly with complex diseases. In this paper, we investigate the effects of both true (within‐family) comorbidity and spurious comorbidity due to ascertainment bias on the validity of both the parental and sibling control...
Large, population‐based samples and large‐scale genotyping are being used to evaluate disease/gene associations. A substantial drawback to such samples is the fact that population substructure can induce spurious associations between genes and disease. We review two methods, called genomic...
Multipoint linkage analysis gives increased power over single‐point analysis to detect linkage for quantitative trait loci (QTL). Besides increased power, the use of multipoint methods makes it possible to estimate not only the location but also the magnitude of the QTL. Currently, two methods...
Previous work using two‐point linkage analysis showed that performing a lod score (LOD) analysis twice, once assuming dominant and once assuming recessive inheritance, and then taking the larger of the two values (designated MMLS) usually has more power to detect linkage than any other method...
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