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Pancreatic acinar cells are critical in gastrointestinal physiology and pancreatitis and may be involved in pancreatic cancer. Previously, a short rat pancreatic elastase promoter has been widely utilized to control acinar cell transgene expression. However, this partial sequence does not confer...
Arterial tortuosity syndrome (ATS, MIM# 208050) is a rare autosomal recessive connective tissue disease, mainly characterized by widespread arterial involvement with elongation, tortuosity, and aneurysms of the large and middle‐sized arteries (Callewaert et al., 2008, Hum Mutat 29:150–158)....
An increasing number of genes have been implicated in skeletal muscle fiber diversity. To study the contribution of diverse genetic elements to the regulation of fiber‐type composition, we generated a transgenic mouse in which CRE recombinase expression is driven by muscle‐specific regulatory...
A standard development embryological series is the primary basis to organize information of any embryological study and is also used to determine the age of eggs and embryos in field conditions. In this article, we calibrate developmental series of the broad‐snouted caiman, Caiman latirostris,...
Members of the novel gene family Gasdermin (Gsdm) are exclusively expressed in a highly tissue‐specific manner in the epithelium of skin and the gastrointestinal tract. Based on their expression patterns and the phenotype of the Gsdma3 spontaneous mutations, it is inferred that the Gsdm family...
Diagram of the head of a day 48 embryo of Caiman latirostris (Crocodylia: Alligatoridea). See the paper by Iungman et al. in this issue.
Endothelin receptor B (Ednrb) plays a critical role in the development of melanocytes and neurons and glia of the enteric nervous system. These distinct neural crest‐derived cell types express Ednrb and share the property of intercalating into tissues, such as the intestine whose muscle...
TAK1 binding protein 1 (TAB1) binds and induces autophosphorylation of TGF‐β activating kinase (TAK1). TAK1, a mitogen‐activated kinase kinase kinase, is involved in several distinct signaling pathways including non‐Smad pathways for TGF‐β superfamily members and inflammatory responses...
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