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Msx1 and Msx2, two members of the Msx gene family, encode homeoprotein transcription factors and play critical roles during mouse development. Because of the redundancy between the two genes, many of these roles can only be studied in double Msx1; Msx2 mutants. However, these animals die around...
The serine‐threonine kinase Akt regulates multiple biological processes. An important strategy to study Akt signaling in different tissues is targeted activation of this pathway in vivo. The current studies describe the generation of a mouse model that combines a double reporter system with...
The Notch signal transduction pathway is highly conserved and governs many developmental decisions in metazoans. The ligand Delta, and its receptor Notch, are often expressed in complementary patterns during Drosophila postembryonic development. Notch signaling is thought to play a role in...
Actin‐depolymerizing factor (ADF) and cofilin constitute a family of key regulators of actin filament dynamics. ADF/cofilin is inactivated by phosphorylation at Ser‐3 by LIM‐kinases and reactivated by dephosphorylation by Slingshot (SSH) family phosphatases. Defects in LIM kinases or...
Histological section showing beta‐galactosidase staining (blue) of embryonic day 12.5 heart from a new cysteine‐rich protein (Cspr1) transgenic mouse strain crossed to the R26R cre reporter mouse. Staining is found specifically in the outflow tract cushions and myocardial cuff. See the paper...
CXCR7 is a G‐protein coupled receptor that was recently deorphanized and shown to have SDF1 and I‐TAC as high affinity ligands. Here we describe the characterization of CXCR7‐deficient mice that were generated to further investigate the function of this receptor in vivo. Expression analysis...
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