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10.1002/dvg.1020090306.abs We have created a transgenic mouse which showed an autosomal dominant mutation of facial development. This facial malformation was characterized by a short snout and a twisted upper jaw. All offspring showing the dysmorphic phenotype carried the injected gene. In order...
10.1002/dvg.1020090302.abs The tissue specificity of the lethal yellow mutant was investigated by separation of blastocyst tissues. Embryos from experimental (Ay/ae × Ay/ae) and control (ae/ae × Ay/ae) crosses of the AG/CamPa inbred strain were recovered at 3.5 days post coitum, cultured for 24...
10.1002/dvg.1020090303.abs Aldehyde oxidase (AO) and pyridoxal oxidase (PO) distribution patterns were determined in the imaginal wing discs for a series of strains of Drosophila melanogaster heterozygous for different Minute mutations. The mutant severity ranged from very weak to strong. The...
10.1002/dvg.1020090305.abs The patterns of synthesis of heat shock proteins (hsp) and heat sensitivity to elevated temperatures in larvae of Drosophila melanogaster reared since hatching at 20°C (warmreared) or at 10°C (cold‐reared) were compared. The pattern of hsp synthesis in salivary...
10.1002/dvg.1020090304.abs Several lines of transgenic mice were produced by pronuclear injection of a full‐length cDNA encoding a mutant dihydrofolate reductase (DHFR, E.C. 188.8.131.52). The mutation causes altered enzyme kinetics for folate reduction as well as low affinity for methotrexate...
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