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Drosophila cells of a diploid clone derived from line Kc were treated with 1 mM H 2 O 2 , for 1 to 20 minutes. Dot blot and Northern blot analysis of RNAs extracted from control and treated cells showed that the transcriptional activation of the 6 heat-shock genes tested was early, and maximal...
Larvae of the southern armyworm, Spodoplera eridania , are highly polyphagous feeders which frequently encounter and feed upon plants containing high levels of prooxidant allelochemicals. While ingestion of moderate quantities of prooxidants can be tolerated by these larvae, ingestion of larger...
We have studied the effects of oxygen radical scavengers on the inactivation of ss ΦX174 DNA by the semi-quinone free radical of the antitumor agent etoposide (VP 16-213), which was generated from the ortho-quinone of etoposide at pH ≥ 7.4. A semi-quinone free radical of etoposide is thought...
The photosensitizer flavin mononucleotide (FMN), in conjunction with the reducing agents diethylenetria-minepentaacetic acid (DTPA), hydrazine and hydroxylamines derived from nitroxides, generates superoxide radicals in a strictly light-dependent reaction in aerobic solution. Addition of...
It has been suggested that antioxidant administration to rats would reduce the physiological response to stress. In the present experiment adult male rats were given diets supplemented with vitamin E for one or seven days before they were subjected to immobilization stress. Vitamin E...
Cells respond to metabolic perturbations by producing specific stress proteins. Exposure of mammalian cells to various forms of oxidative stress induces haem oxygenase, the rate-limiting enzyme in haem degradation. This response is proposed to represent an antioxidant defence operating at two...
Heparin (2,000 U/kg, i.v.) increases the plasma superoxide dismutase (SOD) activity by 2-3 times after 5min. followed by a gradual decrease. A high dose of heparin (4 × 10 3 and 10 × 10 3 U/kg) exhibits a lower increase in the release of SOD. Ischaemic paw oedema in mice was suppressed by...
When a variety of ferric chelates are reacted with hydrogen peroxide in phosphate buffer deoxyribose is damaged and this damage is protected against by formate, thiourea and mannitol. Damage done by ferric complexes of citrate, EDTA, NTA, EGTA and HEDA is substantially inhibited by superoxide...
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