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Objective: Although serotonin reuptake inhibitors (SRIs) are approved for the treatment of obsessive-compulsive disorder (OCD), most OCD patients who have received an adequate SRI trial continue to have clinically significant OCD symptoms. The purpose of this study was to examine the effects of...
Background: To compare venlafaxine and selective serotonin reuptake inhibitors (SSRIs; fluoxetine, sertraline, paroxetine, fluvoxamine, and citalopram) in the treatment of depression. Methods and Materials: Meta-analysis of 34 randomized, double-blind studies identified by a worldwide search of...
Objective: Impairments in adaptive life skills are a major source of disability in patients with schizophrenia. The relationship between adaptive life skills in real world settings and performance on neuropsychological tests may be complicated by other factors that interfere with deployment of...
Objective: With a multitude of antidepressants available, predictors of response to different classes of antidepressants are of considerable interest. The purpose of the present study was to determine whether norepinephrine transporter gene (NET) and serotonin transporter gene (5-HTT)...
This exercise is designed to test your comprehension of material presented in this issue of FOCUS as well as your ability to evaluate, diagnose, and manage clinical problems. Answer the questions below, to the best of your ability, on the information provided, making your decisions as you would...
To date, most therapies of treatment-refractory psychiatric disorders involve modifications of existing pharmacological treatments and/or cognitive therapies. However, many of these strategies are unable to bring these disorders into remission; therefore, a substantial number of patients with...
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