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Spinal motor neurons of Sprague–Dawley rats were examined to determine which of the neuronal isoforms of actin (β or γ) upregulate following axon injury. In situ hybridization studies showed greater β-actin mRNA levels but no change in γ-actin mRNA levels—suggesting that axon regrowth...
Intraparenchymal injections of glutamate analogues into the diencephalon near the supraoptic (SON) and paraventricular nucleus (PVN) of the hypothalamus selectively spare magnocellular neuroendocrine cells. In this study we investigated for the first time the susceptibility of this neuronal...
Nonimmunosuppressant immunophilin ligands have been shown to have neurotrophic properties in rodent models of Parkinson's disease (PD), although little is known about the effects of these ligands in primates. The immunophilin ligand, GPI-1046, promotes the regeneration of dopamine (DA) cells in...
The distribution of corticotropin-releasing factor (CRF), the development of CRF-binding sites, and the age at which application of CRF elicits a physiological response have been described previously in the postnatal mouse cerebellum. The intent of the present study was to determine the cellular...
Neural injury is known to trigger inflammatory changes, including the synthesis of proinflammatory cytokines such as interleukin-1-beta (IL1β), tumor necrosis factor-alpha (TNFα), and interferon-gamma (IFNγ) (G. Raivich, L. L. Jones, C. U. A. Kloss, A. Werner, H. Neumann, and G. W. Kreutzberg,...
Theefficient and large-scale generation of neural progenitor cells for neural grafting in the treatmentof neurological diseases has been a challenge. Here we describe the isolation and successful propagation of neural progenitor cells from adult rat bone marrow. Unfractionated bone marrow...
The effects of acute hyponatremia on severe traumatic brain injury (TBI) in 35 adult male Sprague–Dawley rats were studied in a replicated focal and diffuse injury rat model. Such effects were assessed by the cerebral contusion volume and axonal injury (AI) densities, determined by quantitative...
Neurotrophic factors regulate a variety of cellular processes, including neuronal survival during development and after injury. For instance, brain-derived neurotrophic factor (BDNF) can prevent the death of dopaminergic substantia nigra neurons in rats. Most neurotrophic factor receptors, such...
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