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Conventional electrophysiological intracellular recording techniques were used to test the hypothesis that enhanced calcium entry via voltage-gated calcium channels or the N -methyl- d -aspartate (NMDA) subtype of glutamate receptor–channel complex may be a primary pathological mechanism...
We investigated alterations in nerve growth factor (NGF) and ciliary neurotrophic factor (CNTF) contents during treatment with epalrestat, an aldose reductase inhibitor (ARI), on streptozotocin (STZ)-induced diabetic neuropathy in rats. Diabetic rats showed a statistically significant reduction...
Long-term treatment of Parkinson's disease with dopamine-replacing agents such as l -3,4-dihydroxyphenylalanine ( l -DOPA) is compromised by many side-effects, most notably involuntary movements, l -DOPA-induced dyskinesia. Acute challenge with dopamine-replacing drugs elicits a rotational...
Recent studies suggest that women are at greater risk for Alzheimer's disease than men and that estrogen replacement can help to reduce the risk and severity of Alzheimer's-related dementia in postmenopausal women. We have hypothesized that the increased risk for Alzheimer's-related dementia is...
A proliferation assay based on the production of mini-units of tissue was adopted and modified for the simultaneous determination of cell proliferation rate and the effect of genistein in rat cerebral cortex. Mini-units of tissue were produced from rat cerebral cortex immediately after killing...
We have recently established a rat substantia nigra (SN) slice preparation in which a sensitive index of excitatory amino acid (EAA) toxicity was degeneration of the dendritic arbor of catecholamine neurons labelled by immunostaining for tyrosine hydroxylase (TH). The present study examined the...
Olfactory receptor neurons (ORNs) are unique because they can be replaced by stem cells throughout life. Previous studies have demonstrated that adult mouse olfactory epithelium (OE) injured by exposure to ZnSO 4 through nasal irrigation can stimulate stem cell mitotic activity in situ , which...
This paper reports that endolymphatic hydrops causes a significant reduction of retrogradely labeled cell bodies of the ipsilateral trigeminal ganglion following application of horseradish peroxidase in the cochlea. We previously showed that the trigeminal ganglion is a source of primary sensory...
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