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Lambs prematurely delivered by cesarean section and term lambs were supported on ventilators and studied over a period of 2 days. Sequential measurements of ventilatory requirements, lung compliance, and arterial pH, pO 2 , and pCO 2 values documented the course of the lung disease. In five...
We measured the total rate of fatty acid synthesis in alveolar type II cells freshly isolated from the lungs of adult rats. The rate of incorporation of 3 H from 3 H 2 O into cellular fatty acids was linear during 3-hr incubations and was very brisk ( 18 ng-atoms 3 H/10 6 cells/hr ± 2 ( mean ±...
Blotchy is an X-linked recessive mutation at the “Mottled” locus in the mouse. The affected blotchy male (Blo/Y) mouse from an inbred genetic background demonstrates morphologic and physiologic abnormalities consistent with emphysema in adult life. Breeding of Blo/Y mice has been difficult...
The structural features of the ovine pleura are described using light, scanning, and transmission electron microscopy. Extensive sampling of the visceral and parietal pleura revealed considerable variation in both surface morphology and pleural interstitial anatomy. Variations of mesothelial...
To investigate the effect of vitamin A on the occurrence of lipid droplets in alveolar fibroblasts, light and electron microscopic studies were carried out on the lungs of Syrian golden hamsters fed on diets with a low, normal, or high vitamin A content for a period of 17 weeks. The feeding of...
Lung slices from fetal rats of streptozotocin-diabetic mothers incorporated ( 3 H ) glycerol and ( 3 H ) choline into phosphatidylglycerol and disaturated phosphatidylcholine, respectively. When compared to age-matched fetuses from nondiabetic mothers, lung phosphatidylglycerol synthesis of...
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