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CL 273,547 is a novel nonbenzodiazepine with anxiolytic activity, but with a lesser tendency to produce sedative effects. CL 273,547 was established as a discriminative stimulus in rats ( ). Triazolam and CL 284,846 substituted for CL 273,547 and decreased response rates. Buspirone did not...
Theoretical predictions involving memory associations between alcohol use and its positive outcomes were examined. In 2 preliminary studies, the availability from memory of outcomes from drinking was investigated. In subsequent studies, a measurement paradigm was used that decreased the...
Wisconsin Card Sorting Test (WCST) performance was assessed in 24 heavy smokers and 12 nonsmokers recruited from universities in the United States and Japan. Half of the smokers performed the WCST after abstaining from tobacco for 12 hr, whereas the remaining smokers smoked a cigarette of their...
The acute behavioral effects of triazolam (0, 0.375, and 0.75 mg/70 kg) and caffeine (0, 250, and 500 mg/70 kg), alone and in combination, were assessed in 9 male volunteers. Ss received all possible dose combinations according to a Latin square design. Triazolam administered alone dose...
Amperozide and clozapine are antipsychotic drugs that act primarily as antagonists at 5-hydroxytryptamine (5-HT ) sites. In different groups of rhesus monkeys ( ) receiving food, cocaine, or alfentanil as a consequence of responding on FR 30 schedules, the antipsychotic drugs produced...
Studying prevalence of (3rd ed., rev., ) drug dependence among Americans 15–54 years old, we found about 1 in 4 (24%) had a history of tobacco dependence; about 1 in 7 (14%) had a history of alcohol dependence; and about 1 in 13 (7.5%) had a history of dependence on an inhalant or controlled...
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