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Intracerebroventricular (i.c.v.) injection of choline (75–300 μg) produced a dose-dependent increase in blood glucose levels. Pre-treatment with the nicotinic acetylcholine receptor antagonist, mecamylamine (50 μg, i.c.v.) blocked the hyperglycemia induced by choline (150 μg, i.c.v.), but...
We investigated the antioxidative activities and the effects on acute inflammation in mice of a novel diaminouracil derivative, CX-659S (( S )-6-amino-5-(6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxamido)-3-methyl-1-phenyl-2,4(1 H ,3 H )-pyrimidinedione). CX-659S showed potent scavenging...
We have investigated the effect of 2(4-((2-carboxymethyl)phenyl)ethylamino)-5′- N -ethylcarboxamidoadenosine (CGS 21680), a potent and selective agonist at adenosine A 2A receptors, on pulmonary inflammation induced by allergen challenge in the ovalbumin-sensitised, Brown Norway rat. Aerosol...
Cephalosporin antibiotics are thought to be excreted into the urine via organic anion transporters (OATs). The purpose of this study was to elucidate the interaction of human-OATs with various cephalosporin antibiotics, using proximal tubule cells stably expressing human-OAT1, human-OAT3 and...
Pharmacogenetics will be of substantial help in the field of affective disorders pharmacotherapy. The possible definition of a genetic liability profile for drug side-effects and efficacy will be of great help in treatments that need weeks to months to be effective. During the last few years, a...
Human urotensin II-(1–11) and its N-terminally shortened analogues, human urotensin II-(4–11)-OH and human urotensin II-(4–11)-NH 2 are potent vasoconstrictor peptides in isolated rat thoracic aorta. Human urotensin II-induced tonic aorta ring contractions are inhibited by the Ca 2+ channel...
Through the screening of our in-house chemical compound library, we found a novel melanin-concentrating hormone (MCH) receptor antagonist, T-226296, a (−) enantiomer of N -(6-(dimethylamino)-methyl)-5,6,7,8-tetrahydro-2-naphthalenyl)-4′-fluoro(1,1′-biphenyl)-4-carboxamide. T-226296...
In the present study, murine RAW 264.7 macrophages were incubated with poly- l -lysine-derived advanced glycosylation end products (PLL-AGEs) to examine cyclooxygenase-2 protein expression. Treatment of RAW 264.7 cells with PLL-AGEs caused the dose-dependent expression of cylooxygenase-2 but not...
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