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Aim: To assess how often the clinical syndrome (CS) of heart failure is attributable to alternative, including non‐cardiac, explanations. Methods and results: Cross‐sectional evaluation of 739 community participants aged ≥45 years. Subjects with ≥2 symptoms or signs (dyspnoea or fatigue,...
Aims: To assess the relationship between body mass index (BMI), mortality and mode of death in chronic heart failure (CHF) patients; to define the shape of the relationship between BMI and mortality. Methods and results: We performed a post‐hoc analysis of 5010 patients from the Valsartan Heart...
Background: Long-term prognosis of coronary artery disease (CAD) patients is worsened when stress ischemia persists on treatment, but the relationship with adverse cardiac remodelling had never been investigated. Aim: To analyze changes in blood markers of fibrosis in patients with chronic CAD...
Aim: To assess how often the clinical syndrome (CS) of heart failure is attributable to alternative, including non-cardiac, explanations. Methods and results: Cross-sectional evaluation of 739 community participants aged ≥45 years. Subjects with ≥2 symptoms or signs (dyspnoea or fatigue,...
Aim: To compare the patients' self-assessment of the severity of their symptoms with a physicians assessment and to evaluate the ability of self-assessed symptoms and ejection fraction (EF) to predict long-term survival in heart failure patients. Method: Patients ( n =332) evaluated symptoms...
Background: Myocardial viability assessment in severely dysfunctional segments by dobutamine stress echocardiography (DSE) is less sensitive than nuclear scanning. Aim: To assess the additional value of using the recovery phase of DSE after acute beta‐blocker administration for identifying...
Background: Anaemia and renal dysfunction are common in patients with heart failure (HF). Most studies involve western cohorts with ischaemic aetiology receiving treatment likely to impair renal function. Aims: To investigate the frequency of anaemia and renal dysfunction and the relationship...
Background: Previous studies suggest that vascular endothelial growth factor (VEGF) is a regulator of naturally occurring angiogenesis. However, whether VEGF plays a role in cardiomyocyte apoptosis is not known. Aim: To investigate the effects of intramyocardial injection of VEGF165 cDNA on...
Background Osteoprotegerin (OPG) and the receptor activator of nuclear factor‐kB ligand (RANKL), two cytokines regulating bone remodeling, have recently been raised as potential pathogenetic factors in cardiovascular diseases. We have studied circulating and myocardial OPG and RANKL in patients...
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