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Aims The clinical characteristics, initial presentation, management, and outcomes of patients hospitalized with new‐onset (first diagnosis) heart failure (HF) or decompensation of chronic HF are poorly understood worldwide. REPORT‐HF (International REgistry to assess medical Practice with...
Aims The aim of this study was to investigate the clinical picture and outcome of cardiogenic shock and to develop a risk prediction score for short‐term mortality. Methods and results The CardShock study was a multicentre, prospective, observational study conducted between 2010 and 2012....
Aims The release of the B‐type natriuretic peptide (BNP) is increased in heart failure (HF), a condition associated with oxidative stress. BNP is known to exert anti‐inflammatory effects including suppression of neutrophil superoxide (O2−) release. However, BNP‐based restoration of...
Aims Analysis of 24‐h Holter recordings was a pre‐specified substudy of SHIFT (Systolic Heart Failure Treatment with the If Inhibitor Ivabradine Trial) for exploring the heart rhythm safety of ivabradine and to determine effects of ivabradine on 24‐h, daytime, and night‐time heart rate...
Aims Heart failure (HF) patients show cognitive and mood impairments, including short‐term memory loss and depression, that have an adverse impacting on quality of life and self‐care management. Brain regions, including the hippocampus, a structure significantly involved in memory and mood,...
Background Increases in serum creatinine with renin–angiotensin–aldosterone system (RAAS) inhibitors can lead to unnecessary discontinuation of these agents. The dual‐acting angiotensin receptor neprilysin inhibitor LCZ696 improves clinical outcome patients with heart failure with reduced...
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