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Aims We sought to test whether an increase in the clopidogrel maintenance dose results in increased inhibition of platelet aggregation. Methods and results Sixty patients after pre-treatment with 600 mg of clopidogrel and within 12 h after successful PCI were included in this trial. They were...
Systemic inflammatory diseases represent a large group of rare diseases that may involve all organs and also the heart. The three layers of the heart can be affected and some manifestations such as pericarditis in systemic lupus erythematosus are rather well known, yet others are not known even...
Aims We studied plasma erythropoietin (EPO) levels and their relation with CD34 + VEGFR-2 + (mature and progenitor endothelial cells) and CD34 + CD133 + VEGFR-2 + , or CD34 + CD117 + VEGFR-2 + (early/immature endothelial progenitors) cells in patients with acute myocardial infarction (AMI)....
Aims In aortic stenosis (AS), adverse remodelling of the valves may depend on altered local regulation of pro- and antifibrotic systems. We have recently shown that angiotensin-converting enzyme (ACE), which generates profibrotic angiotensin II and inactivates antifibrotic bradykinin (BK), is...
Recently, several drugs for non-cardiovascular diseases have ceased marketing because of cardiovascular risk, highlighting the importance of evaluating the cardiovascular safety of new drugs even if not intended for cardiovascular diseases. Assessing and ensuring acceptable cardiovascular safety...
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