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The gonadotropin-releasing hormone (GnRH) controls pituitary gonadotropin biosynthesis and secretion and therefore it is indispensable in regulating reproductive function. We have studied the effects of a short term treatment (7-days) of a GnRH-agonist (GnRH-Ag) in vivo (a) on reproductive...
The A6 cell line, derived from Xenopus kidney, is an in vitro model of cortico-steroid mediated transepitheial Na + transport stimulation. We report the apparent down-regulation of mineralocorticoid receptor levels in A6 cells, in response to the presence of the synthetic glucorticoid...
An estrus stage-specific proteinase of an estimated molecular weight of 600 kDa was detected in uterine luminal fluid of the rat. Estradiol administrated sc to adult female ovariectomized and immature rats induced its production. The 600 kDa protein was stable to sodium dodecyl sulfate...
The role played by endogenous substance P (SP) in the regulation of hypothalamo-pituitary-adrenal (HPA) axis was investigated in the rat. Normal and ether-stressed (2 mm ether-vapor inhalation) or cold-stressed (20 min at 4°C) animals were given a bolus subcutaneous injection of 100 nmol...
The purpose of this study was to examine the effects of exercise on anterior pituitary hormones (adrenocorticotropic hormone (ACTH), leutinizing hormone (LH) and growth hormone) as well as on cortisol at low altitude (350 meters below the sea level) and to compare these effects with those at a...
TGF-β strongly inhibits the mitogenic effect of growth factors such as insulin-like growth-I (IGF-I) on thyroid follicular cells. To study the mechanism of this inhibiting action, the effect of TGF-β 1 on tyrosine phosphorylation of 175kDa substrate induced by IGF-I was investigated in FRTL-5...
The effect of L-triiodothyronine (L-T 3 )-induced hyperthyroidism on reproduction in female rats was studied. Treatment groups used were normal control, 1, 2, 4, 8, and 16 μg L-T 3 /100 g body weight (b.w.)/day. Subcutaneous injections of L-T 3 began the first day of estrus until day 1 or day 19...
Studies of the growth hormone (GH) secretory dynamics of children with normal and idiopathic short stature (ISS) have revealed that the regulation of the GH-somatomedin (GHS) axis can differ significantly among normal individuals. Information on the GH secretion in idiopathic tall stature (ITS)...
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