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Prolonged (12–day) sodium deprivation strikingly raised both basal plasma aldosterone concentration (PAC) (114%) and plasma renin activity (PRA) (200%), and lowered ANF blood level (-30%). Acute ANF bolus administration produced a dose-dependent decr e ase in PAC in both normally-fed and...
Intranuclear distribution of rat liver glucocorticoid receptors was examined. When the ( 3 H)TA-receptor complex-bound nuclei were digested with micrococcal nuclease, the ( 3 H)TA-receptor complex sedimented coincident with mono-, di- and trinucleosomes on a glycerol gradient. The specific...
The present study addressed the possibility that regional differences exist in the typical patterning of anterior pituitary hormones seen over the estrous cycle. The results show that LH in the rostral area of the pituitary, significantly higher than in other regions on diestrus, rises markedly...
Preliminary studies, both in vitro and in vivo were carried out to understand the physiological significance of LH receptor binding inhibitors isolated from ovine corpora lutea. Among the four active fractions tested, while UM-2R-III administered intraperitoneally suppressed both hMG and...
In a recent study, we have shown that the autiarrhythmic drug, amiodarone caused significant elevations of serum rT 3 levels and inhibition of the peripheral conversion of T 4 to T 3 (Kannan et al. Endocrinology
Studies were carried out in 3T3-L1 fibroblasts to determine the effect of sphingolipids and corticosteroids on concanaval in A stimulated glucose uptake. Sphinganine (40 μM) and sphingosine (40 AND 100 μM) significantly inhibited concanavalin A stimulated glucose uptake (P<0.025 & <0.005)....
Procedures for the isolation of luteinizing hormone receptor binding inhibitor (LHRBI) from crude extracts of ovine corpora lutea are described. Microsomal pellets recovered by differential centrifugation of homogenates of fresh corpora lutea were stored at -20° C for 3 weeks and then extracted...
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