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The key to applying targeted imaging to personalized medicine is the choice of the right radiolabeled probe for the right target for the right disease following the lead of pharmaceutical development. The imaging approach differs depending on whether the target is a single disease control point...
Thrombocytopenia is a common medical problem. The first generation thrombopoietic agents, recombinant THPO and ‘megakaryocyte growth and development factor’ (PEG-rHuMGDF) entered clinical trials, but their development was discontinued owing to neutralizing auto-antibodies cross-reacting with...
Interest in Translational Research has been growing rapidly in recent years. In this collision of different data, technologies and cultures lie tremendous opportunities for the advancement of science and business for organisations that are able to integrate, analyse and deliver this information...
Cardiotoxicity of some targeted therapeutics, including monoclonal antibodies and small-molecule inhibitors, is a reality. Herein we will examine why it occurs, focusing on molecular mechanisms to better understand the issue. We will also examine how big the problem is and, more importantly, how...
The mortality rate in cancer patients demands novel therapy. One of the novel approaches developed in recent decades includes immunotoxins. Cancer cells frequently have specific growth factor receptors/antigens overexpressed on their surface; this is the principle of selective targeting of...
Male pattern baldness affects up to half of the male Caucasian population by middle age, and almost all Caucasian men by old age. Especially in younger men, this heritable form of hair loss can have significant psycho-social consequences. Although approved pharmacological agents exist to manage...
This article presents a system for drug name recognition and classification in biomedical texts. The system combines information obtained by the Unified Medical Language System (UMLS) MetaMap Transfer (MMTx) program and nomenclature rules recommended by the World Health Organization (WHO)...
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