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Ganoderma lucidum is used in traditional Chinese medicine for the treatment of cancers. There now fresh evidence of how G.lucidum inhibits prostate cancer cellproliferation.
BioFocus was founded in 1997 as a provider of chemistry services and libraries to the pharmaceutical and biotechnology communities. BioFocus can offer high-technology medicinal chemistry, biology (assay development and screening), computational chemistry and ADME-Tox services in drug discovery.
Tissue engineering is still in its infancy, although some research projects have already come close to clinical application. The increasing significance of drug delivery in the future will help progress tissue engineering.
The benefits of nicotine for a host of diseases have stimulated the quest for better and more selective nicotinic drugs, with natural products providing a template for drug design.
Development of site-selective drug-carrier delivery systems has not paid sufficient attention to meet the fundamental pharmacokinetic and pharmacodynamic requirements and consequently has failed to deliver.
The pharmacokinetic profile should be a primary consideration in the selection of a drug candidate, ultimately contributing to its eventual clinicalsuccess or failure. It is now recognized that selection of a ‘robust’ candidate requires a balance between efficacy, safety and drug metabolism...
Finding new drug targets will require a reorientation from the present emphasis upon understanding of the mechanistic and genetic basis of disease to one that is centred upon a more clinical and physiological approach
As the immunopathology of asthma has become better defined, novel targets have been identified and agents developed and tested for the treatment of asthma and allergic diseases. These approaches have achieved variable, but occasionally striking, degrees of clinical success.
A novel drug that could treat the underlying cause of multiple sclerosis has shown good results in a Phase II study.
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