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A comment on the use of multistage adaptive designs for clinical trials
Twenty years after the discovery of HIV, scientists are a step closer to the development of a HIV vaccine.
A longer patent lifespan leads to more profits. When a corporation's duty is to maximize profits, why should it share its profits with competitors? There are strategies to take advantage of a U.S. patent's limited window of opportunity.
Updates on the latest patent news and business collaborations in the pharmaceutical and biotech industry.
The high number of new immunotherapies that show promising effects in animal models but nevertheless fail in patients can be reduced by preclinical tests in non-human primate disease models. The last few decades of the 20th century have shown an intensified search for safer and more effective...
A review of the highlights from SMI's Advances in High Throughput Screening conference, held in London, UK, on 21–22 January 2004.
Compound lipophilicity is of key importance to P450 binding affinity and enzyme selectivity. Here, lipophilicity is discussed with reference to the human drug-metabolizing P450 enzymes of families CYP1, CYP2 and CYP3. From an extensive compilation of log P values for P450 substrates, and by...
A discussion of the pharmacological targeting of Bax in the treatment of neurodegeneration.
An unexpected mitochondrial gene, PINK1, provides a link between mitochondria and Parkinson's disease.
Peptide-based drugs are now viable alternatives to biopharmaceuticals, such as antibodies. Most of the past limitations of peptides have been removed by new technologies, so that peptides now face similar hurdles to antibodies. Phage-display technology provides novel peptides that bind protein...
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