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GABA is a major inhibitory neurotransmitter in the CNS where it regulates neuronal excitability. These actions of GABA are mediated through GABA receptor subtypes, one of which is the GABA B receptor (GBR). The development of specific agonists and antagonists for GBRs has led to a better...
In the increasingly competitive pharmaceutical industry, novel targets and mechanisms of action are being investigated in the search for the high-quality drugs required by patients and regulatory authorities. As a result of this move towards novel targets, the initial stage of drug discovery,...
In this two part review, the current status of influenza research is summarized in the context of inhibitor design and discovery. In Part 1, published in the August edition of Drug Discovery Today, the authors considered therapeutic approaches to influenza through interference with early phases...
The conjugation of polysaccharides to carrier proteins generally enhances polysaccharide immunogenicity and renders the immune response T-cell dependent. Such enhancement of immunogenicity has made the use of conjugate vaccines possible in populations that are otherwise unresponsive to...
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