Within the last year
Within the past 3 years
1 - 7 of 7 articles
Purine and pyrimidine nucleoside analogs (NAs) are antimetabolites commonly used in cancer therapy. Administered as prodrugs, NAs permeate the mambrane using specialized transporters. Following phosphorylation, they interfere with multiple cellular pocessess inducing cytotoxicity. Toxic effects...
The fact that conventional and newly emerging treatment procedures like chemotherapy, catalytic therapy, photodynamic therapy, and radiotherapy have not succeeded in reversing the outcome of many cancers alternative treatment options has been explored. This study documents the identification of...
Most cancer drugs are quite potent and represent a potential hazard to chemists conducting their synthesis. Chemical development teams must therefore integrate proper handing techniques for such compounds into their development plans. We describe the synthesis of the drug busulfan using barrier...
IPI‐504 (retaspimycin hydrochloride) is an Hsp90 inhibitor that is the subject of multiple clinical trials for the treatment of cancer. IPI‐504 is an aqueous soluble (>200 mg/ml) hydroquinone hydrochloride salt of 17‐(allylamino)‐17‐demethoxygeldanamycin (17‐AAG), a quinone derivative...
Optimizing study designs is an important responsibility for applied statisticians supporting clinical trials. We describe the study design for an early‐phase non‐Hodgkin's lymphoma trial with two co‐primary endpoints; however, evaluation of the second endpoint on a subject is conditional on...
The cannabinoid receptor one (CB1) is a class A G‐protein‐coupled receptor thought to bind ligands primarily within its helical bundle. Evidence suggests, however, that the extracellular domain may also play a role. We have previously shown that the C‐terminus of the extracellular loop 2 of...
The wide interest in developing improved therapies for cancer has led to a dramatic increase in the number of highly potent active pharmaceutical ingredients (HAPIs) under development and in use today. The following is an overview of the “cradle‐to‐grave” health risk issues that must be...
Read and print from thousands of top scholarly journals.
Sign up with Facebook
Sign up with Google
Already have an account? Log in
Save this article to read later. You can see your Read Later on your DeepDyve homepage.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Sign Up Log In
To subscribe to email alerts, please log in first, or sign up for a DeepDyve account if you don’t already have one.
To get new article updates from a journal on your personalized homepage, please log in first, or sign up for a DeepDyve account if you don’t already have one.