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A quantitative structure‐activity relationship (QSAR) analysis of 10 structurally diverse set of compounds recently reported as cyclooxygenase (COX) inhibitors has been performed using ClogP, CMR, aromatic substituent constants, and suitable indicator variables. These revealed several important...
The promise of pharmacogenomics lies in the ability to tailor patient therapies based on a genetic risk profile. This risk profile may be based on known literature single nucleotide polymorphisms or it may be encompassed by genome‐wide scans for risk alleles. In either case, it is the...
Thymol is a natural product, which has antioxidant activity. 4‐Morpholinomethyl‐2‐isopropyl‐5‐methylphenol (THMO), and 4‐Pyrrolidinomethyl‐2‐isopropyl‐ 5‐methylphenol (THPY) were synthesized by reacting thymol with formaldehyde and, respectively, morpholine or pyrrolidine....
Biological response modifiers (BRMs) are a family of compounds defined as agents or approaches that modify the host response to pathogens. A serum‐derived small peptide, termed Innate Immune Regulatory Factor (IIRF), stimulates the immune response through a natural killer cell–dependent...
The estrogen receptor (ER) is an important drug target with allosteric characteristics that binds orthotopic hormones and other ligands. A recently developed scintillation proximity (SPA)‐based assay for high‐throughput screening (HTS) of compound libraries was used to identify novel estrogen...
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