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The structure–activity relationships (SAR) of 8‐phenyl‐1,3‐dipropylxanthine derivatives in binding to recombinant human A2B adenosine receptors were explored, in order to identify selective antagonists. Based on the finding of receptor selectivity in MRS 1204, containing an...
A number of congeners of the antitumor compound L‐canaline, (l‐2‐amino‐4‐(aminooxy)butyric acid), a structural analog of L‐ornithine, have been synthesized and their growth‐inhibitory effects evaluated in cultured MIA‐PaCa‐2 cells, a human pancreatic adenosarcoma, by the...
Polyclonal antisera generated to peptides corresponding to the carboxy termini of the seven cloned rat P2X receptors were compared using membranes from CHO‐K1 or 1321N1 cells expressing recombinant rat or human P2X receptors (rat P2X3, P2X4, and P2X5 and human P2X1, P2X2, P2X6, and P2X7)....
To elucidate the role of platelets in brain damage during focal cerebral ischemia, the effect of YM337, a glycoprotein IIb/IIIa antagonist, on infarct areas and neurologic deficits was measured in monkeys with thrombotic distal middle cerebral artery occlusions. Distal middle cerebral arteries...
This work describes the preparation and the physicochemical properties of atovaquone‐loaded liposomes. It also describes drug release from the liposomes. As many factors can influence liposome stability, we studied several formulations, including different concentrations of atovaquone,...
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