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The cellular electrophysiological effects of MS‐551, a pure class III antiarrhythmic agent lacking beta‐blocking activity, were compared with those of d‐sotalol and dofetilide in canine Purkinje fibers and ventricular muscles and in guinea pig atrial muscles using the standard...
Pioglitazone and other antidiabetic thiazolidinediones appear to overcome insulin resistance by affecting an unidentified early event in insulin action. Because attempts to determine changes in insulin receptors in tissues from thiazolidinedione‐treated diabetic animals are complicated by...
Bidisomide (SC‐40230) is a unique new antiarrhythmic agent. In this study the canine intravenous (i.v.) antiarrhythmic doses of bidisomide (9 ± 1 mg/kg), disopyramide (8 ± 1 mg/kg), cibenzoline (8 ± 2 mg/kg), and propafenone (6 ± 0.5 mg/kg) were established in a 24 h coronary ligation...
The analgesic efficacy of the combination of acetyl salicylic acid (ASA), a nonsteroidal anti‐inflammatory drug (NSAID), and morphine, a μ‐opiate receptor agonist, was evaluated in the pain‐induced functional impairment in the rat (PIFIR) model. Groups of 6 rats received either vehicle,...
The effects of SR 57746A during acquisition and on stabilized performance of a delayed alternation task in a Skinner Box (Model E 10.10, Coulbourn Instruments, Lehigh Valley, PA) were investigated in aged rats (22–26 months old). Test sessions consisted of repeated trials during which animals...
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