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The effects of treatment, on plasma lipids in patients with Type II hypercholesterolemia, for 8–24 weeks was determined with pravastatin (PR) and cholestyramine (CH) given alone or in combination. The first 8 weeks of treatment included a parallel placebo (P) control, while the subsequent...
Binding studies in rat brain membranes have shown that (3H)CP‐96,501 is a selective, high affinity radioligand for 5‐HT1B receptors. Additional studies with (3H)CP‐96,501 in brain tissues of several other species were undertaken to investigate its utility in detecting this receptor subtype....
The major pathway for the outflow of aqueous humor from the anterior chamber of the eye is the trabecular meshwork/Schlemm's canal system. The meshwork is composed of connective tissue beams that are ensheathed by trabecular cells; these cells derive their nutrition from the aqueous humor and...
L‐alpha‐glycerylphosphorylcholine (alpha‐GPC) has been proposed for the treatment of age‐related cognitive disturbances. In the rat the compound prevents the learning impair‐ ment and the retrograde amnesia both induced by scopolamine and this effect appears to be correlated with an...
To assess effectiveness and tolerability of intravenous bidisomide, 16 patients (aged 57 ± 15 years) with ≥ 100 premature ventricular complexes (PVCs)/hr received a 10‐min infusion of bidisomide at 0.4 (n = 4), 0.75 (n = 4), 1.0 (n = 4), or 1.35 (n = 4) mg/kg body weight. Mean PVCs and...
There is convincing evidence that re‐oxygenation of ischemic organs is associated with the formation of oxygen free radicals and increases in cell calcium that exacerbate the ischemic injury. The objective of the present studies was to determine whether felodipine, a dihydropyridine calcium...
We tested (in an inhibitory avoidance test) ramipril and the n‐octyl‐ester of ramipril (RA‐octil; Hoe 065), which was shown to have no significant influence on plasma‐converting enzyme (CE) activity or blood pressure in spontaneously hypertensive rats. In addition, the influence of the...
The effects of S 9977 (1,3,7‐trimethyl 8‐(3‐(4‐diethylaminocarbonyl‐l‐piperazinyl) 1‐propyl)‐3,7‐dihydro(1H)2,6‐purinedione hydrochloride) on the amnesias induced by scopolamine, diazepam, and electroconvulsive shock (ECS) were studied in a passive avoidance procedure in the...
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