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1,2,3,4‐tetrahydro‐5‐amino acridine (THA), a cholinesterase inhibitor currently under investigation for use in the treatment of senile dementia, exhibited mutagenic activity with and without metabolic microsomal S‐9 activation against tester strain TA97a in the Salmonella typhimurium...
Three commonly used anesthetic agents (pentobarbital, chloralose‐urethane, and inactin) were studied in a rat model. The radiolabeled microsphere technique was used to evaluate rats anesthetized (no reaction to pain stimulus) with the three drugs as compared to awake unanesthetized animals. Of...
The autonomic effects of clovoxamine, a possible new antidepressant, were compared with placebo, imipramine, and amitriptyline in a double‐blind, repeated‐measures, latin‐square study design, using 16 healthy volunteers. Salivary flow, pupillary response, near‐point accommodation, and...
Baclofen was compared with diazepam for ability to block the interoceptive discriminative stimulus produced by the anxiogenic drug pentylenetetrazol (PTZ). Male hooded rats of the Long Evans strain were trained in two‐lever operant chambers to respond for food reward. Presses on one lever were...
This report begins by reviewing data showing that the effects of acute exposure to stressful situations can grow with the passage of time (time‐dependent sensitization; TDS) and then proceeds to suggest that the clinical syndromes of panic, delayed post‐traumatic stress disorder, and bulemia...
The lipid composition of human immunodeficiency virus (HIV) was investigated. Several strains of HIV were found to contain considerable amounts of lipid. The major lipid constituents were cholesterol and phospholipid with a molar ratio close to one. This lipid composition and membrane apparent...
The present study examined effects of the stereoisomers of celiprolol and further examined cardiostimulatory effects of celiprolol. In the anesthetized, ganglionicblocked dog, both I‐ and d‐celiprolol, 3 mg/kg, i.v., showed cardioselective beta adrenoceptor antagonist activity, although...
Intraperitoneal injection of scopolamine at a dose of 0.5 mg/kg produced a marked decrease after 15 min in the acetylcholine (ACh) content of the frontal and temporal cortices and the hippocampus in the rat. In the parietal and occipital cortices and the striatum, the decrease in ACh content was...
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