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The effect of cholecystokinin octapeptide (CCK‐8) on the performance of platform‐jumping avoidance behavior was investigated in the rat. CCK‐8 was injected subcutaneously once in different doses immediately after training trials. The number of avoidance responses remained high 5 and 10 days...
Proof of the protective properties against cerebral hypoxic hypoxidosis of a new potentially nootropic drug, tenilsetam (TEN), were studied as compared with 5 mg co‐dergocrine mesylate (CDM) in a double‐blnd, placebo‐controlled trial. Hypoxic hypoxidosis was induced by a fixed gas...
Yohimbine potentiation of lethality in mice has been used as a model for the prediction of antidepressant agent (Quinton, 1963). However, prior to death or at sublethal doses, yohimbine induces clonic convulsions. In Swiss‐Webster mice (20–28 g) individually placed in clear plastic cylinders,...
The effect of various pharmacological interventions on the collecting phase of cystometrogram (CMG) has been investigated by means of a new cystometric procedure in urethane‐anesthetized rats. The method involves the transvesical infusion, through a needle inserted in the bladder dome, of warm...
Recent research in the area of peripheral dopamine (DA) receptors has led to the identification of two distinct subtypes of DA receptors, activation of which results in marked changes in the cardiovascular and renal function consisting of hypotension, bradycardia, diuresis, and natriluresis....
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