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Thirty‐five patients with stable angina pectoris (AHA functional class II or III) entered a 5‐week short‐term study to determine the efficacy and safety of a transdermal therapeutic system of nitroglycerin (TDN; 5 to 20 mg/day). Nineteen of these patients were available for a final...
Arecoline has been reported to improve memory deficits, but a relatively short half‐life and adverse cardiovascular effects have limited its use. The purpose of this study was to compare the cardiovascular effects of a bolus administration with those of an infusion of arecoline in anesthetized...
Vinpocetine is an eburnamenine derivative reported to protect the brain from ischemia, both in experimental animals and in man. Its effects have been directly compared to those of vincamine, phenytoin, and cinnarizine in the Fisher rat following bilateral carotid artery occlusion (BCAO). Upon...
Proceeding from the fact that the production of prostacyclin is decreased during atherosclerosis, which likely leads to the development of an atherosclerotic lesion, we assumed that addition of the exogenous prostacyclin would facilitate regression of atherosclerotic manifestations. To test this...
The rabbit tooth pulp (RTP) assay was compared to the 55°C mouse hot plate (MHP) assay for detecting the antinociceptive actions of carfentanil, sufentanil, fentanyl, alfentanil, meperidine, morphine, ketamine, and nefopam. Except for meperidine, all the the opioid agonists exhibited lower ED50...
Rimcazole is a novel antipsychotic agent free of extrapyramidal side effects as judged by its profile in animal behavioral models and by results of early clinical trials in acute schizophrenic patients. The present study shows that rimcazole is different biochemically from the typical and...
The α2‐adrenoceptor agonists clonidine and lidamidine were found to be effective in decreasing colonic propulsion in conscious mice after oral administration. Propulsive activity was measured using evacuation of a rectally administered glass bead as the endpoint. The ED50's of clonidine and...
SK&F 86466, 6‐chloro‐3‐methyl‐2,3,4,5‐tetrahydro‐1‐H‐3‐benzazepine, is a potent and selective antagonist of the α2‐adrenoceptor in vitro. This compound produced a small pressor response accompanied by a marked bradycardia when administered i.v. to the pithed normotensive rat....
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