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The reproductive and developmental toxicity of cyclohexane was assessed in a two-generation reproduction study with Crl:CD® BR rats and in developmental toxicity studies with Crl:CD®BR rats and Hra:(NZW)SPF rabbits. The animals were exposed whole-body to atmospheric concentrations of 0, 500,...
Adult male rats pressed a lever on a multiple fixed ratio-fixed interval (FR20-FI120 sec) schedule of food presentation, and after attaining a stable baseline subjects received an acute inhalation exposure to cyclohexane vapor (0 ppm, 500 ppm, 2000 ppm, or 7000 ppm) for 6 hr. During the operant...
Oxymetholone is a synthetic androgen, structurally related to testosterone. It is currently used to treat anemias, but has also been abused as a performance enhancing anabolic steroid by the sport community. Concern about its suspected immunomodulatory properties provided the incentive for a...
Background : Plasmodium yoelii nigeriensis (P. y. nigeriensis ) produces lethal malaria infection in Swiss albino mice. Reactive oxygen species (ROS) such as superoxide anion, hydrogen peroxide along with endogenously produced tumor necrosis factor (TNF) have been implicated in the pathogenesis...
The purpose of this investigation was to demonstrate the feasibility of a method to quantitatively measure achievement (or non-achievement) of reduced pollution generation at the source process in manufacturing, known as pollution prevention. This is societally useful since managers often need...
Chloro- S -triazine herbicides (cyanazine (CZ), atrazine (AZ), simazine (SZ)) increase mammary tumors in Crl:CD® BR rats but not in F-344 rats or in mice. A nongenotoxic mechanism was investigated since the chloro- S -triazines are negative in short-term tests for genotoxicity. An in vivo...
Inhalation studies were conducted to determine the potential toxicity and/or potential neurotoxicity of cyclohexane. Groups of rats and mice were exposed to 0, 500, 2000, or 7000 ppm concentrations of cyclohexane vapor 6 hr/day, 5 days/week for 14 weeks. Subgroups of rats and mice were further...
Ammonium perfluorooctanoate is a potent synthetic surfactant used in industrial applications. It rapidly dissociates in biologic media to perfluorooctanoate (CF 3 (CF 2 ) 6 CO 2 − ), which is the anion of perfluorooctanoic acid (PFOA, CF 3 (CF 2 ) 6 COOH). PFOA is a peroxisome proliferator...
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