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ABSTRACT Various chemical groups were evaluated for their skin sensi-tization potential in the guinea pig. In general, amines, acetani-lides, pyridines, piperidines, and sulfones were positive in the guinea pig test. Since these tests were done over a period of years, any further...
ABSTRACT While the total annual volume of caffeine has increased over the years, the actual per capita daily intake has not. This is based on the fact that the quantity of caffeine in a soft drink is about the same or, in the case of diet drinks, less than in 1961 when the original GRAS...
ABSTRACT The objective of the present investigation was to determine the influence of lead acetate on kinetic parameters of γ-Glutamyl Transpeptidase (GGT) in brain homogenates from 15 and 30 day old rat pups. Determinations of maximal velocity (Vmax) indicated that the Vmax of GGT from 15 day...
ABSTRACT Carminomycin, an anthracycline antibiotic discovered in the Soviet Union, possesses antitumor activity and is chemically related to adriamycin and daunorubicin. The toxic effects of carminomycin observed in single-dose toxicologic studies in mice iv (4.5–13.5 mg/m 2 ) and po...
ABSTRACT The effect of concomitant administration in normal dogs of phenobarbital with either oral free digoxin, oral liposome-entrapped digoxin or intravenous liposome-entrapped digoxin were examined Phenobarbital induced a transient rise in serum digoxin concentrations during concomitant...
ABSTRACT The toxic effects of 5-AZA-2'-deoxycytidine (5-AZA-CdR) administered as a 12 hr. i.v. continuous infusion to CD2F 1 (Balb/c × DBA/2) mice were investigated. This i.v. route of administration of 5-AZA-CdR was chosen because it produced a potent anti-neoplastic effect in leukemic mice and...
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