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53BP1 is an established player in the cellular response to DNA damage and is a canonical component of ionizing-radiation induced foci – that cadre of proteins which assemble at DNA double strand breaks following radiation exposure and which are readily visualized by immunofluorescence...
Highlights ► Polη can be activated dependent and independent of PCNA-Ub during both SHM and DDT. ► PCNA-Ub and Polη are necessary, but not essential, for efficient DDT of UV-lesions. ► PCNA-Ub/ Polh independent DDT of UV-lesions involves Rev1 and Rev3.
Highlights ► Processivity of DNA glycosylases can cause double-strand breaks at clustered lesions. ► We engineered pyrimidine dimer-specific DNA glycosylases with reduced processivity. ► We developed an assay to quantitatively measure incisions at clustered abasic sites. ► Biochemical and...
Highlights ► Mitotic growth arrest by PJ34 is PARP1 + 2 independent. ► PJ34 growth arrest occurs in cells from diverse genetic backgrounds. ► PJ34 causes a G2/M growth arrest, independent of ATM, p53 or Chk1. ► PJ34 growth arrest is caffeine sensitive and UCN01 insensitive. ► ATR is...
Highlights ► We analyzed 768 SNPs in DNA repair genes and H2AX phosphorylation levels. ► We found an association between SNPs in MRE11A and XPA with DSBR activity. ► We suggested that DSBR requires both DSBR and non-DSBR systems. ► Further functional experiments to better investigate DNA...
Highlights ► DNA Flap unwinding by Mph1 explains how it dissociates D-loops. ► Mph1 proficiently regresses the DNA replication fork. ► Mph1 processes the Holliday junction by branch migration.
This article is an overview of the author's involvement in theoretical and experimental research on genetic recombination and DNA repair, and also on the enzymic modification of cytosine in DNA to 5-methyl cytosine. It includes the history of the discovery of the central intermediate in genetic...
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