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Chronic obstructive pulmonary disease (COPD) is a highly prevalent airway disease characterized by an abnormal inflammatory response of the lungs to noxious particles and gases. Cigarette smoking remains a major risk factor for COPD development; however, little is known about its effect on human...
Mitochondrial manganese superoxide dismutase (MnSOD), encoded by the SOD2 gene, represents a major cellular defense against environmental carcinogens that cause oxidative stress. Two single-nucleotide polymorphisms â9 T>C (V16A in the MnSOD mitochondrial targeting sequence) and â102 C>T...
The replication-associated (Rep) protein of porcine circovirus (PCV) was suggested to play an essential role in the replication and translation of viral DNA. In this study, one monoclonal antibody (mAb) specific for Rep protein of porcine circovirus type 1 (PCV1), two mAbs against Rep protein of...
Endometrial cancer (EC) is the most common malignancy of the female reproductive system in the industrialized world. Similar to other common diseases, gene variations are believed to be able to alter an individual's predisposition to developing the disease. The CHEK2 gene encodes a tumor...
The interactions of the steroidal and nonsteroidal estrogenâplatinum (Pt) (II)âbased anticancer drugs 16Î²-hydroxymethyl-16Î±-8-(2-pyridin-2-yl-ethylamino)-3,6-dioxaoctyl-1,3,5(10)-estratrien-3,17Î²diol dichloroplatinum (II) (JPM-39),...
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