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In vivo percutaneous penetration and tissue distribution of radioactivity following a topical application of 14 C-labeled butyl 2-chloroethyl sulfide (BCS) were determined in the laboratory rat. Up to 70% of the topical BCS was lost by evaporation. Only a portion of BCS in the skin was extracted...
This study was designed to investigate the use of adult female hairless guinea pigs, bred at Charles River Laboratories, Inc. (CRL-IAF(HA)BR), as a model for dermal sensitization studies. These animals are euthymic and hairless except for continuous hair growth at the nose and feet. A modified...
Phototoxicity is a skin-cell damage response that follows exposure, in many instances, to a juxtapositional combination of certain chemicals and ultraviolet A (UVA) light. Many known phototoxins are fragrances or components of fragrances. Because of the commercial value of fragrance materials to...
Although guinea pig models of contact hypersensitivity are widely used, less expensive and less time-consuming alternatives are still needed. A new and easy method is described that can help to determine the sensitizing potential of drugs and chemicals in Balb/c mice. In this protocol, the test...
Seventy-one unselected patients with newly diagnosed open angle glaucoma were included in a prospective multicenter study of medical treatment, intraocular pressure response, and adverse drug reactions. Standard data were recorded by the eight ophthalmologists at five visits over a mean interval...
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