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In vivo percutaneous penetration and tissue distribution of radioactivity following a topical application of 14 C-labeled butyl 2-chloroethyl sulfide (BCS) were determined in the laboratory rat. Up to 70% of the topical BCS was lost by evaporation. Only a portion of BCS in the skin was extracted...
This study was designed to investigate the use of adult female hairless guinea pigs, bred at Charles River Laboratories, Inc. (CRL-IAF(HA)BR), as a model for dermal sensitization studies. These animals are euthymic and hairless except for continuous hair growth at the nose and feet. A modified...
Although guinea pig models of contact hypersensitivity are widely used, less expensive and less time-consuming alternatives are still needed. A new and easy method is described that can help to determine the sensitizing potential of drugs and chemicals in Balb/c mice. In this protocol, the test...
Phototoxicity is a skin-cell damage response that follows exposure, in many instances, to a juxtapositional combination of certain chemicals and ultraviolet A (UVA) light. Many known phototoxins are fragrances or components of fragrances. Because of the commercial value of fragrance materials to...
Seventy-one unselected patients with newly diagnosed open angle glaucoma were included in a prospective multicenter study of medical treatment, intraocular pressure response, and adverse drug reactions. Standard data were recorded by the eight ophthalmologists at five visits over a mean interval...
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