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Current safety testing programs for consumer products generally include a test to evaluate potential eye damage by assessing objective irritation in the conjunctivum, iris, or cornea. However, the potential for a product to cause eye discomfort in the form of subjective irritation through...
Dose-effect characterization of various ocular parameters (conjunctival hyperemia and edema, corneal thickness, and corneal epithelial fluorescein permeability) has been obtained for a topically applied cationic surfactant, cetylpyridinium chloride (CPC). At doses of 100 μg and less (applied as...
The studies presented here describe the modulating effect of commonly topically used antiglaucoma, anti-inflammatory, and antibiotic drugs and a preservative of topical drugs on the phagocytosis of latex particles by corneal fibroblasts. Rabbit corneal fibroblasts in cell culture were incubated...
We report an in vitro method for identifying materials with the potential to cause corneal opacity. Monolayers obtained from an established line of rabbit corneal cell epithelium were exposed to test materials and the increase in light absorbance at 360 nm was assessed after 10 min. Responses...
Using mixed rat peritoneal cells, including mast cells, a technique was developed to assess the ability of test materials to cause histamine release. This release was determined fluorimetrically, and noted to be concentration-dependent. This allowed the test materials to be ranked in terms of...
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