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Background: Vaginal pH is a key factor in maintaining a healthy vaginal ecosystem. An increase in vaginal pH is commonly observed during bacterial vaginosis. Objective: This study was undertaken to compare the effects of polycarbophil, a new bioadhesive polymer in gel form, with those of an...
Background: Antihistamines (H 1 -receptor antagonists) are widely prescribed to treat symptoms of seasonal and perennial allergic rhinitis and chronic urticaria. Drowsiness and impairment of cognition and psychomotor performance have been reported as adverse events in many trials, and all...
Background: The Fas-Fas-ligand (FasL) system and tumor necrosis factor-alpha (TNF-α) are involved in immune-mediated liver injury. They have also been shown to play a critical role in the pathogenesis of acute graft-versus-host disease (GVHD). Objective: The aim of the present study was to...
Background: A number of antithrombotic agents are available for use in patients with arteriosclerotic disease. However, no guidelines have been established for their clinical use. Objective: The purpose of this study was to compare the ability of various antithrombotic agents to inhibit...
Background: The increases in influenza-related hospitalizations and mortality despite the availability of the influenza vaccine and antiviral drugs such as amantadine and rimantadine underscore the need for better treatments for influenza. Objective: This review describes the epidemiology,...
Background: Beta-blockers are effective in patients with effort angina pectoris. However, there have been no previous reports on the long-term effects of beta-blocker therapy using ambulatory electrocardiographic (AECG) monitoring according to a MEDLINE ® search. Objective: This study was...
Background: The risk of gastric carcinoma is increased in persons with a positive family history of the disease. Previous findings suggest that free radicals are involved in both the initiation and promotion of carcinogenesis. Objective: The aim of this study was to assess whether alterations in...
Background: It has been observed that neonatal patients receiving extracorporeal membrane oxygenation (ECMO) require larger doses of sedatives than do non-ECMO patients to achieve similar levels of sedation. Objective: The purpose of this study was to determine whether drug disposition of...
Background: Differences in the pharmacokinetic and pharmacodynamic variables of angiotensin II receptor blockers (ARBs) have been cited as potentially important causes of differential clinical efficacy with respect to the magnitude and duration of the antihypertensive response. Objective: The...
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