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The effect of etofibrate and nicanartine on plasminogen activator inhibitor type-1 (PAI-1) production in vitro and on plasma PAI-1 activity in vivo was determined. Both agents decreased baseline and transforming growth factor-β induced—PAI-1 synthesis in cultured human vascular endothelial and...
In a double-masked, placebo-controlled, crossover study, the effects of cisapride (10 mg three times daily for 2 weeks), a gastroprokinetic drug, were evaluated on the gastric emptying and stasis symptoms of seven patients who had chronic gastroparesis more than 1 year after highly selective...
Empiric therapy for febrile granulocytopenic patients is essential but whether monotherapy is as effective as and safer than a combination of antibacterial agents is still controversial. The use of cefoperazone-sulbactam for treatment of febrile granulocytopenic episodes in adult acute leukemia...
The efficacy and tolerability of amlodipine and the extended-release (ER) formulation of felodipine were compared in this multicenter, randomized, double-blind, parallel-group, comparative study involving 201 patients with mild-to-moderate hypertension seen in 22 general clinical practices....
Twelve healthy subject participated in this randomized, double-masked, four-way crossover study to determine treatment schedules for intravenous (IV) administration of various gastric antisecretory drugs. Intragastric pH was monitored continuously for 14 hours after a single IV injection of...
An open-label, prospective trial was conducted to determine the efficacy and safety of tolrestat in patients with peripheral sensorimotor diabetic neuropathy (PSMDN). Twenty-five patients with PSMDN were given 200 mg/d of oral tolrestat for 28 weeks. Significant improvement in paresthesia ( P =...
Over a 3-year period (from 1987 through 1989), the medical charts of 346 patients (between 14 and 89 years of age with male to female ratio of 1.6:1) with brucellosis were reviewed to determine the efficacy of various treatment regimens. Of 92 positive blood cultures, all the isolates were...
In this uncontrolled, unblinded efficacy study, 33 patients with disseminated intravascular coagulatoin (DIC) or the prodromal stage (preDIC) of the condition were treated with nafamostat mesylate (NM) administered intermittently to examine whether this regimen would be as efficacious as the...
This study evaluated treatment of patients affected with duodenal ulcer positive for Helicobacter pylori . We compared patients treated with ranitidine plus amoxicillin plus colloidal bismuth subcitrate (n = 20) with patients treated with omeprazole plus amoxicillin plus colloidal bismuth...
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