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Phosphodiesterase type 5 (PDE5) is an enzyme that catalyzes hydrolytic degradation of cyclic guanosine monophosphate, an essential intracellular second messenger that modulates diverse biologic processes in living cells. Three selective inhibitors of PDE5, sildenafil, vardenafil, and tadalafil,...
This article assesses the effects of lower urinary tract symptoms (LUTS), not including urinary incontinence, on the overall sexual health of women, using literature that includes peer-reviewed articles. This article analyzes a number of studies that provide data on the prevalence and the...
Phosphodiesterase type 5 inhibitors are a mainstay of treatments in patients with organic or psychogenic erectile dysfunction. Many of the patients who have atherosclerotic disease of the penis also have disease of the cardiovascular system. In cardiovascular patients, nitrates are a cornerstone...
Anejaculation due to neurologic disease is a challenging condition for the treating physician. Electroejaculation is effective at inducing ejaculation in such men and has been a mainstay in treatment protocols for many years. New developments within the past few years have allowed for the...
The major risk concern of testosterone replacement therapy in middle-aged and older men is that it may lead to an increase in the incidence and severity of symptomatic benign prostatic hyperplasia (BPH) and prostate carcinoma. While this concern is based on the role of androgens in the...
Initial placebo-controlled trials with sublingual apomorphine showed promising results for the drug as an option in the pharmacologic management of erectile dysfunction (ED). More recent studies propose poor erectile effects by apomorphine sublingual in patients with diabetes and fewer benefits...
Late onset hypogonadism is becoming a more relevant topic because of the aging population, and many older patients are questioning their physicians about treatment for symptoms of declining testosterone. Low testosterone is present in 6% to 12% of the US adult male population and has several...
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